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Comet Assay News

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Journal Articles:

Combining the In Vivo Comet and Micronucleus Assays:  A Practical Approach to Genotoxicity Testing and Data Interpretation (Mutagenesis 2009)

The Comet Assay as an Indicator Test for Germ Cell Genotoxicity (Mutat Res 2009)

Fourth International Workgroup on Genotoxicity Testing:  Results of the In vivo Comet Assay Workgroup (Mutat Res 2007)


Helix3 Poster Presentations:

DNA Reactivity Dose Response Curves Using the Acellular Comet Assay (EMS 2011)

Regulatory Safety Testing with the In Vivo Comet Assay:  Recommendations for Data Interpretation (EMS 2010)

Combining the In Vivo Comet and Micronucleus Assays:  A Practical Aproach to Genotoxicity Testing and Data Interpretation (EMS 2009)

The Combined In Vitro and Acellular Comet Assay:  Understanding Mechanisms of Genotoxicity (EMS 2009)

The Comet Assay:  Breaking from Tradition (EMS 2008)

Interpreting Data from in Vitro Genotoxicity Tests Using the Acellular Comet Assay (EMS 2008)

Target Organ Selection for the In Vivo Comet Assay:  Genotoxicity Versus Turmorigenesis (EMS 2008)

Safety Testing with the in Vitro Comet Assay:  Critical Factors in Protocol Design and Data Interpretation (EMS 2007)

Cytotoxicity and its Impact on the In Vivo Comet Assay (EMS 2007)

Effects of Sample Processing on the Interpretation of In Vivo Comet ASsay Data (EMS 2006)

Dec 2011:  Helix3 develops their acellular comet assay protocol to provide test compound DNA reactivity data for screening and/or for mode of action determination

Nov 2011:  The ICH Steering committee approves the revised ICH S2(R1) Guideline on Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use

Oct 2010:  Helix3 presents Regulatory Safety Testing with the In Vivo Comet Assay:  Recommendations for Data Interpretation

Dec 2009:  To address the new ICH S2(R1) Guidelines, recommendations for conducting combined in vivo comet and micronucleus assays and addressing cytotoxicity is published by Helix3 in Mutagenesis.

Sep 2009:  Genotoxicity testing using the Acellular comet assay developed at Helix3 to minimize false positive in vitro test results.

Aug 2009:  5th International Workgroup on Genotoxicity Tests (IWGT) Meets in Basal Switzerland to Discuss Recommendations for ICH Guideline Revisions.

Jan 2009:  Germ cell genotoxicity testing recommended for product safety.

Oct 2008:  The European Food Safety Authority (EFSA) recommends the use of the in vivo comet assay as a follow up to an in vitro positive.


Mar 2008:  ICH Guidelines for Genotoxicity Testing modified to include the comet assay in the target organ(s).


Jun 2007:  The new chemicals legislation REACH (Registration, Evaluation, Authorisation, and Resriction of Chemicals) enters into force requiring additional testing to improve safety.


Mar 2007:  ECVAM Workshop convenes to discuss methods for reducing false positive in vitro results

Important Publications

Technical Documents and Regulatory Guidelines >>