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The Comet Assay
Introduction
The alkaline version of the comet assay was developed to measure DNA damage (or its repair) in virtually any cell type.  Prior to the comet assay, tests used to measure the potential health risk of exposures to food additives, pharmaceuticals, chemicals, and/or environmental factors were limited to insensitive and often non-specific tests that were inappropriate for assessing the true risk of exposures.  Today, the comet assay can be used to measure the very low levels of DNA damage and/or repair inhibition that may lead to carcinogenesis and other health risks.
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